Primeadine
Primeadine
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Primeadine

Vendor
Oxford Healthspan
Regular price
Dhs. 349.00
Sale price
Dhs. 349.00
Regular price
Sold out
Unit price
per 

Benefits of our Spermidine Supplement Beauty Enhances hair growth and fullness, including eyelashes and eyebrows, and promotes nail growth and strength  Healthy aging Supports memory, cognition and brain and cardiovascular health  Sleep Assists with deeper, sounder sleep and circadian reset  Longevity Boosts autophagy, which declines with age, and promotes cellular renewalWhat is spermidine? Spermidine is a potent polyamine, known for inducing autophagy, which is the body's cellular renewal and recycling process that slows as we age.  Supplementation with spermidine in humans has been shown to support cognition and heart health, promote hormonal balance and improve hair growth and fullness (including eyelashes and eyebrows), and strengthen nails.  Epidemiological studies have correlated higher spermidine levels with longer life.  The gut biome and our tissues produce 2/3 of our body's spermidine. This is known as 'endogenous production'. The final third comes 'exogenously' or externally from our diet.  As we age, spermidine production in our tissues and gut biome begins to fall, reducing autophagy, and therefore cell renewal.Spermidine inhibits 6 of the 9 Hallmarks of AgingStem Cell Exhaustion Stem cells lose their ability to divide as we age, and we are unable to replace cells that have migrated, differentiated, or died. As a result, we show outward symptoms of aging, such as gray hair.  Mitochondrial Dysfunction As cells age, their mitochondria start to lose their integrity due to the build-up of oxidative stress. Compromised mitochondrial function leads to a number of adverse events, such as increased apoptosis induction, that correlate with aging.  Telomere Shortening Shortened telomeres are associated with aging cells that are senescent. As cells divide, the telomere ends of chromosomes get shorter. Eventually, telomerase gets silenced and the telomeres are too short for cells to divide.  Epigenetic Alterations As cells are exposed to environmental factors, they are subject to changes in their genome through epigenetic mechanisms. Such changes accumulate over time and have been correlated with the decline observed in aging cells.  Altered Extracellular Communication As cells age, they show an increase in self-preserving signals that result in damage elsewhere. Altered extracellular communication with aging contributes to decline in tissue health.  Loss of Proteostasis As cells age, environmental stresses add up and mechanisms responsible for maintaining proper protein composition start to decline. Proteins lose their stability, autophagic processes start to fail, and misfolded proteins accumulate.